How to use cerebral vasodilators and metabolic activators.

Accelerated Cytotoxicity Mechanism Screening

By discovering how chemical compounds/xenobiotics cytotoxicity is affected when their metabolic pathways are inhibited or activated, the metabolic pathways that activate versus detoxify chemical compound can be identified. Reactive metabolites contributing to cytotoxicity can also be identified. In this lecture, the pretreatment of inhibitors and activators of xenobiotic metabolizing enzymes as...

Role of Nitric Oxide and ATP-Sensitive K+ Channels in Regulation of Basal Blood Flow and Hypercapnic Vasodilatation of Cerebral Blood Vessels in Rabbit

Background: The mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood. Objective: To investigate the role of nitric oxide (NO) and ATP-sensitive potassium (KATP) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels. Methods: The change in cerebral blood flow was measured by a laser Doppler flowmeter in 18 Ne...

نقش برنامه توانبخشی و بازپروری بر کارآیی متابولیکی و هزینه انرژی بیماران فلج مغزی اسپاستیک دایپلژی

Introduction & Objective: The aim of this study was to compare the resting energy expenditure and metabolic efficiency before and after of aerobic exercise in spastic cerebral palsy children (mean age of 11 years) and also to compare with those of normal children. Materials & Methods : Fifteen dipelegia spastic cerebral palsy children (experimental group) participated in exercise–rehabilita...

Drug therapy in brain ischaemia.

After many years of research, drug treatment in cerebral hypoxia is still controversial and no treatment appears to be firmly established. Not even the mechanisms causing damage have been established (Siesjo, 1981), only that they are linked to a disturbance in the oxygen demand: supply ratio. Enthusiasm for new modes of therapy have waxed and waned. We have witnessed alternating enthusiasm for...

Effect of Activators and Inhibitors on Lactase Activities to Determine its Kinetic Model